Sigma Receptor

Sigma Receptor Related Products (108):

By Effects:	Inhibitors (11) Agonists (26) Antagonists (31) Modulators (6) Control (1) Ligands (4)

Cat. No.	Product Name	Effect	Purity

HY-90002

4-Phenylpiperidine	Ligand	99.9%
4-Phenylpiperidine is a σ receptor ligand with a K_i value of 1980 nM for guinea pig σ receptors. 4-Phenylpiperidine binds to σ receptors. 4-Phenylpiperidine is used in psychiatric disease research.

HY-108511

PB28 dihydrochloride	Modulator	99.63%
PB28 dihydrochloride, a cyclohexylpiperazine derivative, is a high affinity and selective sigma 2 (σ2) receptor agonist with a K_i of 0.68 nM. PB28 dihydrochloride is also a σ1 antagonist with a K_i of 0.38 nM. PB28 dihydrochloride is less affinity for other receptors. PB28 dihydrochloride inhibits electrically evoked twitch in guinea pig bladder and ileum with EC₅₀ values of 2.62 μM and 3.96 μM, respectively. PB28 dihydrochloride can modulate SARS-CoV-2-human protein-protein interaction. PB28 dihydrochloride induces caspase-independent apoptosis and has antitumor activity.

HY-108510

Rimcazole dihydrochloride	Antagonist	99.96%
Rimcazole (BW 234U) dihydrochloride is a carbazole derivative that acts in part as a sigma (σ) receptor antagonist. Rimcazole dihydrochloride also binds with moderate affinity to the dopamine transporter and inhibit dopamine uptake. Rimcazole dihydrochloride can reduce locomotor activity and sensitization. Rimcazole dihydrochloride also can be used for the research of cancer.

HY-108512

PD 144418		98.32%
PD 144418 is a highly affinity, potent and selective sigma 1 (σ1) receptor ligand (K_i values of 0.08 nM and 1377 nM for σ1 and σ2 respectively). PD 144418 devoids of any significant affinity for other receptors, ion channels and enzymes. PD 144418 shows potential antipsychotic activity.

HY-155992

WLB-89462		98.70%
WLB-89462 (Compound 20c) is a selective σ2 receptor ligand (K_i: 13 nM). WLB-89462 has neuroprotective activity. WLB-89462 improves short-term memory impairment induced by Aβ peptide in rats. WLB-89462 has good ADMET profile (good solubility, no CYP inhibition, good metabolic stability, high permeability, brain penetration, and high oral exposure in rodents).

HY-181425

N-Desmethyl xanomeline
N-Desmethyl xanomeline is a pharmacologically active metabolite of Xanomeline (HY-105182). N-Desmethyl xanomeline binds to muscarinic, serotonergic, histaminergic and dopaminergic receptors. N-Desmethyl xanomeline can be used for the research of schizophrenia.

HY-13751

SR-31747		99.66%
SR-31747 is a sigma ligand with immunosuppressive and anti-inflammatory properties. SR-31747 blocks cell proliferation by inhibiting sterol isomerase.

HY-B1216

Oxeladin citrate	Agonist	98.0%
Oxeladin citrate is an orally active and brain-penetrant cough suppressant as well as a selective sigma 1 receptor agonist (K_i = 25 nM). Oxeladin can be used for pulmonary diseases and stroke research.

HY-118901

Opipramol	Antagonist	99.91%
Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA). Opipramol acts primarily as a sigma (σ) receptor agonist and can potently interact with sigma recognition sites with a K_i value of 50 nM. Opipramol can be used for the research of generalized anxiety disorder (GAD).

HY-100985

IPAG	Antagonist	99.84%
IPAG is a potent sigma-1 receptor antagonist with a pK_i of 4.3. IPAG induces apoptosis.

HY-136280

Panamesine		99.54%
Panamesine (EMD 57445) is a sigma receptor ligand, which has a high affinity (IC₅₀ 6 nM) and selectivity for sigma binding sites. Panamesine is a potential atypical neuroleptic agent.

HY-131914A

EST64454 hydrochloride	Inhibitor	98.36%
EST64454 hydrochloride is a selective and orally active sigma-1 receptor antagonist with a K_i of 22 nM. EST64454 hydrochloride has the potential for the research of the pain.

HY-124462

Trifluperidol hydrochloride	Antagonist	99.4%
Trifluperidol hydrochloride is a Sigma-1 receptor antagonist with a K_i value of 3.3 nM. Trifluperidol hydrochloride is used in the study of psychosis.

HY-108512A

PD 144418 oxalate		98.65%
PD 144418 oxalate is a highly affinity, potent and selective sigma 1 (σ1) receptor ligand (K_i values of 0.08 nM and 1377 nM for σ1 and σ2 respectively). PD 144418 oxalate devoids of any significant affinity for other receptors, ion channels and enzymes. PD 144418 oxalate shows potential antipsychotic activity.

HY-136281

DuP 734	Antagonist	98.82%
DuP 734 is a sigma receptor antagonist. DuP 734 is a selective and potent sigma and 5-HT2 receptor ligand with weak affinity for D2 receptors. DuP 734 may have antipsychotic activity without the liability of motor side effects typical of neuroleptics.

HY-N15339

Convolamine	Modulator	99.89%
Convolamine is an alkaloid found in Convolvulus pluricaulis and an effective positive modulator of the sigma-1 receptor (IC₅₀ = 289 nM), exhibiting cognitive and neuroprotective properties.

HY-155484

SOMCL-668	Modulator
SOMCL-668 is a selective and potent sigma-1 receptor allosteric modulator. ?SOMCL-668 shows positive modulation of improvement in social deficits and cognitive impairment induced by the selective sigma-1 agonist PRE084.?SOMCL-668 displays anti-seizure activities and can be used for psychotic illness research.

HY-149854B

AB21 hydrochloride	Antagonist	99.92%
AB21 hydrochloride is a potent and selective S1R antagonist with K_is of 13, 102 nM for S1R and S2R. AB21 hydrochloride has the effect of reducing mechanical hypersensitivity.

HY-RS12910

Sigmar1 Rat Pre-designed siRNA Set A	Inhibitor
Sigmar1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sigmar1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-47228

KB-5492 free base	Inhibitor	99.02%
KB-5492 free base is a potent and selective inhibitor of sigma receptor, inhibits specific [³H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor with an IC₅₀ of 3.15 μM. KB-5492 free base is an anti-ulcer agent.

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